Tridentate hydrazido-hydrazones vanadium complexes: Synthesis, properties and biological activity

Janusz Szklarzewicz; Anna Jurowska; Maciej Hodorowicz; Dariusz Matoga; Ryszard Gryboś; Barbara Filipek; Jacek  Sapa; Monika Głuch-Lutwin; Barbara Mordyl; Grzegorz Kazek

doi:10.5604/01.3001.0013.1485

Authors

Janusz Szklarzewicz Jagiellonian University, Faculty of Chemistry, Poland https://orcid.org/0000-0001-9747-9238
Anna Jurowska Jagiellonian University, Faculty of Chemistry, Poland https://orcid.org/0000-0001-6562-0954
Maciej Hodorowicz Jagiellonian University, Faculty of Chemistry, Poland https://orcid.org/0000-0003-4210-3625
Dariusz Matoga Jagiellonian University, Faculty of Chemistry, Poland https://orcid.org/0000-0002-0064-5541
Ryszard Gryboś Jagiellonian University, Faculty of Chemistry, Poland https://orcid.org/0000-0001-7340-328X
Barbara Filipek Jagiellonian University, Collegium Medicum, Poland https://orcid.org/0000-0001-8487-9945
Jacek Sapa Jagiellonian University, Collegium Medicum, Poland https://orcid.org/0000-0003-4670-1665
Monika Głuch-Lutwin Jagiellonian University, Collegium Medicum, Poland https://orcid.org/0000-0003-1632-6569
Barbara Mordyl Jagiellonian University, Collegium Medicum, Poland https://orcid.org/0000-0001-7906-0353
Grzegorz Kazek Jagiellonian University, Collegium Medicum, Poland https://orcid.org/0000-0003-2023-8182

DOI:

https://doi.org/10.5604/01.3001.0013.1485

Keywords:

vanadium, complex, Schiff base, structure, hydrazides, biological activity

Abstract

Nine new vanadium complexes, with tridentate Schiff base ligand based on 3,5-di-tert-butyl-2-hydroxybenzaldehyde and different hydrazides, are described and characterized. The X-ray crystal structure of complex 8 shows distorted octahedral geometry of vanadium, with ONO ligand in equatorial position. The tridentate Schiff base ligand forms six membered and five-membered chelate rings at the V(V) acceptor center, with the corresponding bite angles being 82.97(9)˚ and 74.48(9)˚. The molecules are gathered by means of intermolecular O-H∙∙∙N hydrogen bond and layered by π∙∙∙π interactions involving the pyridine and phenolate rings. Such interactions expand the structure along the crystallographic a axis. The complexes were characterized by the elemental analyses, IR, UV-Vis, EPR spectroscopy, cyclic voltammetry, thermogravimetry and magnetic susceptibility measurements. The stabilization role of co-ligands is discussed. The cytotoxicity versus HepG2 hepatocytes and inhibition of human recombinant PTP1B was studied.

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Tridentate hydrazido-hydrazones vanadium complexes

Synthesis, properties and biological activity

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