Farmakologiczne aspekty hydrazydów i pochodnych związków hydrazydowych
DOI:
https://doi.org/10.5604/01.3001.0010.7718Słowa kluczowe:
hydrazydy, hydrazonowe- hydrazydy, izoniazyd, phthalhydrazides, tamerit, galavitAbstrakt
Intensywne poszukiwania nowych leków przeciwbakteryjnych, łącznie ze środkami przeciwguźliczymi, dyktowane są występowaniem zjawiska wielolekowej oporności bakteryjnej. Hydrazydy uważane są za kluczowe intermediaty i wartościowy początkowy materiał d la nowych biologicznie aktywnych związków chemicznych. Ocenę biologicznych właściwości przeciwbakteryjnych lub/i przeciwgrzybiczych wykonuje się dla ponad 70% ostatnio zaprezentowanych syntetycznych pochodnych hydrazydowych. Najpowszechniej stosowanym hydrazydem jest przeciwgruźliczy lek izoniazyd/ hydrazyd kwasu izonikotynowego (NIH). Hydrazydowe związki chemiczne posiadają charakterystyczną wspólną grupę funkcjonalną, w której występuje wiązanie kowalencyjne azot-azot, z czterema podstawnikami, z których przynajmniej jeden stanowi acyl, z kolei pochodne związki hydrazynowe nie posiadają grupy acylowej. Hydrazydy mogą być dalej sklasyfikowane na podstawie rodzaju pierwiastków przyłączonych do tlenu: karbohydrazydy, sulfonohydrazydy, fosfodihydrazydy, hydrazydy hydrazonowe oraz hydrazydy ftalowe. Poza właściwościami przeciwbakteryjnymi i przeciwgrzybicznymi, pochodne związki hydrazydowe stały się ostatnio interesujące z uwagi na ich właściwości przeciwzapalne. Ftalowa pochodna hydrazydowa tamerit/galavit została pomyślnie wprowadzona do terapii u ludzi.
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Prawa autorskie (c) 2017 Państwowa Wyższa Szkoła Zawodowa w Tarnowie & Autorzy
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