Perspectives of pharmacological intervention promoting liver regeneration
DOI:
https://doi.org/10.5604/01.3001.0012.1372Keywords:
liver regeneration, stem cells therapy, macrophage reprogramming, pharmacotherapy of liver diseasesAbstract
Effective drug therapy promoting liver regeneration is a challenging goal in pharmacotherapy of liver diseases. Several plant phytochemicals recommended in traditional medicine from over hundred plants have been investigated for its use in various liver disorders. Regeneration of injured liver depend on a proliferative potential of mature hepatocytes as well as different subsets of intrahepatic and extrahepatic stem/progenitor cells. In clinical trials a stem cell therapy resulted in a limited improvement of liver functions. Animal studies have demonstrated the involvement of bone marrow-derived stem/progenitor cells in liver regeneration. For this reason, the pharmacological activation of endogenous stem cells and pharmacological control of macrophage phenotypic polarization could be an effective method of mobilizing progenitor cells to injured liver.
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Ortiz-Lopez, C., Lomonaco, R., Orsak, B., Finch, J., Chang, Z., Kochunov, V. G., … & Cusi, K. (2012). Prevalence of prediabetes and diabetes and metabolic profile of patients with nonalcoholic fatty liver disease (NAFLD). Diabetes care, 35(4), 873–878. Google Scholar
Karkhanis, J., Verna, E. C., Chang, M. S., Stravitz, R. T., Schilsky, M., Lee, W. M., & Brown, R. S. (2014). Steroid use in acute liver failure. Hepatology, 59(2), 612–621. Google Scholar
Kwon, Y. J., Lee, K. G., & Choi, D. (2015). Clinical implications of advances in liver regeneration. Clinical and molecular hepatology, 21(1), 7–13. Google Scholar
Danilova, I.G., Kalota, H., et al. (2018). Pharmaceuticals in liver failure and regeneration: From hepatotoxicity to hepatoprotective potential of drugs. Almanach (Pol) 2018, in press. Google Scholar
Michalopoulos, G. K. (2017). Hepatostat: liver regeneration and normal liver tissue maintenance. Hepatology, 65(4), 1384–1392. Google Scholar
Liu, W. H., Ren, L. N., Wang, T., Navarro-Alvarez, N., & Tang, L. J. (2016). The involving roles of intrahepatic and extrahepatic stem/progenitor cells (SPCs) to liver regeneration. International journal of biological sciences, 12(8), 954. Google Scholar
Lehwald, N., Duhme, C., Wildner, M., Kuhn, S., Fürst, G., Forbes, S. J., … & Schulte am Esch, J. (2014). HGF and SDF-1-mediated mobilization of CD133+ BMSC for hepatic regeneration following extensive liver resection. Liver International, 34(1), 89–101. Google Scholar
Riehle, K. J., Dan, Y. Y., Campbell, J. S., & Fausto, N. (2011). New concepts in liver regeneration. Journal of gastroenterology and hepatology, 26(s1), 203–212. Google Scholar
Tsolaki, E., & Yannaki, E. (2015). Stem cell-based regenerative opportunities for the liver: state of the art and beyond. World journal of gastroenterology, 21(43), 12334. Google Scholar
Zhai, R., Wang, Y., Qi, L., Williams, G. M., Gao, B., Song, G., & Sun, Z. (2018). Pharmacological Mobilization of Endogenous Bone Marrow Stem Cells Promotes Liver Regeneration after Extensive Liver Resection in Rats. Scientific reports, 8(1),3587. Google Scholar
Danilova, I.G., Yushkov, B.G., et al. (2018). Migration of macrophages and bone marrow stem cells to regenerating liver promoted by sodium phthalhydrazide in mice. Biomed. Pharmacother. BIOPHA_2018_1254, submitted. Google Scholar
Lanthier, N., Lin-Marq, N., Rubbia-Brandt, L., Clément, S., Goossens, N., & Spahr, L. (2017). Autologous bone marrow-derived cell transplantation in decompensated alcoholic liver disease: what is the impact on liver histology and gene expression patterns?. Stem cell research & therapy, 8(1), 88. Google Scholar
Tayyeb, A., Azam, F., Nisar, R., Nawaz, R., Qaisar, U., & Ali, G. (2017). Regenerative Medicine in Liver Cirrhosis: Promises and Pitfalls. In Liver Cirrhosis-Update and Current Challenges. InTech, 236–256. Google Scholar
Koyama, Y., & Brenner, D. A. (2017). Liver inflammation and fibrosis. The Journal of clinical investigation, 127(1), 55–64. Google Scholar
Zheng, D., Wang, Y., Cao, Q., Lee, V. W., Zheng, G., Sun, Y., & Harris, D. C. (2011). Transfused macrophages ameliorate pancreatic and renal injury in murine diabetes mellitus. Nephron Experimental Nephrology, 118(4), e87-e99. Google Scholar
Danilova, I. G., Bulavintceva, T. S., Gette, I. F., Medvedeva, S. Y., Emelyanov, V. V., & Abidov, M. T. (2017). Partial recovery from alloxan-induced diabetes by sodium phthalhydrazide in rats. Biomedicine & Pharmacotherapy, 95, 103–110. Google Scholar
Abidov, M.T. (2016). N-heterocyclic pharmaceuticals for humans. Almanach (Pol), 11, 74–80. Google Scholar
Abidov, M.T. (2018). New N-heterocyclic pharmaceuticals for humans. Part II. Pharmacological and biochemical characterization of hydrazide derivatives. Almanach (Pol), 12, 73–80. Google Scholar
Nagoyev, B.C., Abidov, M.T., et al. (2005). In: [Chronic viral hepatitis: Immunopathogenic, clinical-diagnostic and therapeutic aspects] (Russian), Guripp Adigea Maikop. Google Scholar
Li, H., & Tu, Z. (2017). The Role of Monocytes/Macrophages in HBV and HCV Infection. In Biology of Myelomonocytic Cells. InTech, Chapter 4. Google Scholar
Yang, D., Wang, Z. Q., Deng, J. Q., Liao, J. Y., Wang, X., Xie, J., & Lü, M. H. (2015). Adipose-derived stem cells: A candidate for liver regeneration. Journal of digestive diseases, 16(9), 489–498. Google Scholar
Viswanathan, P., Kapoor, S., Kumaran, V., Joseph, B., & Gupta, S. (2014). Etanercept blocks inflammatory responses orchestrated by TNF-α to promote transplanted cell engraftment and proliferation in rat liver. Hepatology, 60(4), 1378–1388. Google Scholar
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