Assessment of sexual life and social life in people with multiple sclerosis




multiple sclerosis, rehabilitation, assessment, socialization, sexual life


Introduction: Multiple sclerosis is a debilitating condition that affects the central nervous system and is most common in young people. Over time, the relapses associated with the disease can cause damage, and within ten years of onset, half of patients may experience progressive symptoms. Unfortunately, once a patient enters a progressive stage, there is no longer any improvement or remission, though some patients may experience a longer period of stability.
Objectives: The goal of this study is to examine the relationship between social and sexual life in patients with multiple sclerosis, considering the progressive nature of the disease, the fluctuating psychological impact, and the impact on their reproductive abilities.
Methods: The study utilized the Multiple Sclerosis Quality of Life Questionnaire to assess the participants. This questionnaire measures quality of life by asking generic and specific questions related to multiple sclerosis, with a total of 18 items addressing specific needs such as fatigue, cognitive function, sexual function, daily activities, social interaction, and more.
Results: The results indicated that most women with multiple sclerosis reported decreased lubrication, while men’s main concern was satisfying their partner. The majority of participants reported being neither satisfied nor dissatisfied with their sexual and social life. The frequency of sexual dysfunction was found to be higher in women with multiple sclerosis compared to the general population, with decreased libido being the most commonly reported issue. Individuals with primary progressive multiple sclerosis were found to have significantly increased problems with sexual function.
Conclusion: This study found a correlation between social and sexual life for individuals with multiple sclerosis. As their social life worsened, their sexual life and reproductive capacity were also negatively impacted.


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Unger KL, Levin LI, Hollis BW, Howard NS, Ascherio A. Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. JAMA. 2006;296(23):2832-2838. doi: 10.1001/jama.296.23.2832. DOI:   Google Scholar

Trajkovski EV. Medicinski osnovi na invalidnosta. Skopje: Filozofskifakultet, Institut za defektologija; 2008.   Google Scholar

Nouri N, Tabesh G, Saboori A, et al. Protective and risk factors in multiple sclerosis. Int J Med Rev. 2019;6(2):51-58. doi: 10.29252/IJMR-060205. DOI:   Google Scholar

Matsui M. Multiple sclerosis immunology for clinicians. Neurology Asia. 2008;(13):195-198.   Google Scholar

Wucherpfennig KW, Strominger JL. Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein. Cell. 1995;80:695-705. doi: 10.1016/0092-8674(95)90348-8. DOI:   Google Scholar

Kira JI, Kanai T, Nishimura Y, et al. Western versus Asian types of multiple sclerosis: Immunogenetically and clinically distinct disorders. Ann Neurol. 1996;40(4):569-574. doi: 10.1002/ana.410400405. DOI:   Google Scholar

Misu T, Onodera H, Fujihara K, et al. Chemokine receptor expression on T cells in blood and cerebrospinal fluid at relapse and remission of multiple sclerosis: Imbalance of Th1/Th2-associated chemokine signaling. J Neuroimmunol. 2001;114(1-2):207-212. doi: 10.1016/s0165-5728(00)00456-2. DOI:   Google Scholar

Matsui M, Araya S-I, Wang H-Y, Matsushima K, Saida T. Differences in systemic and central nervous system cellular immunity relevant to relapsing – remitting multiple sclerosis. J Neurol. 2005;252(8):908-915. doi: 10.1007/s00415-005-0778-z. DOI:   Google Scholar

Feinstein A. The neuropsychiatry of multiple sclerosis. Can J Psychiatry. 2004;49(3):157-163. doi: 10.1177/070674370404900302. DOI:   Google Scholar

Sadovnick AD, Eisen K, Ebers GC, Paty DW. Cause of death in patients attending multiple sclerosis clinics. Neurology. 1991;41(8):1193-1196. doi: 10.1212/wnl.41.8.1193. DOI:   Google Scholar

Hernán MA, Olek MJ, Ascherio A. Geographic variation of MS incidence in two prospective studies of US women. Neurology. 1999;53(8):1711-1718. doi: 10.1212/wnl.53.8.1711. DOI:   Google Scholar

Ebers GC, Sadovnick AD, Dyment DA, Yee IM, Willer CJ, Risch N. Parent-of-origin effect in multiple sclerosis: observations in half-siblings. Lancet. 2004;363(9423):1773-1774. doi: 10.1016/S0140-6736(04)16304-6. DOI:   Google Scholar

Guo Z-N, He S-Y, Zhang H-L, Wu J, Yang Y. Multiple sclerosis and sexual dysfunction. Asian J Androl. 2012;14(4):530-535. doi: 10.1038/aja.2011.110. DOI:   Google Scholar

Mostert S, Kesselring J. Effects of a short-term exercise training program on aerobic fitness, fatigue, health perception and activity level of subjects with multiple sclerosis. Mult Scler. 2002;8(2):161-168. doi: 10.1191/1352458502ms779oa. DOI:   Google Scholar

Patti F, Ciancio MR, Cacopardo M, et al. Effects of a short outpatient rehabilitation treatment on disability of multiple sclerosis patients: A randomised controlled trial. J Neurol. 2003;250(7):861-866. doi: 10.1007/s00415-003-1097-x. DOI:   Google Scholar

Rietberg MB, Brooks D, Uitdehaag BMJ, Kwakkel G. Tratamiento con ejercicios para la esclerosis multiple. La Biblioteca Cochrane Plus. 2007;2:1-28.   Google Scholar

Wallin MT, Page WF, Kurtzke JF. Multiple sclerosis in US veterans of the Vietnam era and later military service: race, sex, and geography. Ann Neurol. 2004;55(1):65-71. doi: 10.1002/ana.10788. DOI:   Google Scholar

Whitacre CC. (2001). Sex differences in autoimmune disease. Nat Immunol. 2001;2(9):777-7 80. doi: 10.1038/ni0901-777. DOI:   Google Scholar

Sundström P, Juto P, Wadell G, et al. An altered immune response to Epstein-Barr virus in multiple sclerosis: A prospective study. Neurology. 2004;62(12):2277-2282. doi: 10.1212/01.wnl.0000130496.51156.d7. DOI:   Google Scholar

Marrie RA. Environmental risk factors in multiple sclerosis aetiology. Lancet Neurol. 2004;3(12):709-718. doi: 10.1016/S1474-4422(04)00933-0. DOI:   Google Scholar

Layh-Schmitt G, Bendl C, Hildt U, et al. Evidence for infection with Chlamydia pneumoniae in a subgroup of patients with multiple sclerosis. Ann Neurol. 2000;47(5):652-655. DOI:<652::AID-ANA15>3.0.CO;2-5   Google Scholar

Lennon VA, Wingerchuk DM, Kryzer TJ, et al. A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis. Lancet. 2004;364(9451):2106-2612. doi: 10.1016/S0140-6736(04)17551-X. DOI:   Google Scholar

Matsuoka T, Matsushita T, Kawano Y. et al. Heterogeneity of aquaporin-4 autoimmunity and spinal cord lesions in multiple sclerosis in Japanese. Brain. 2007;130(Pt 5):1206-1223. doi: 10.1093/brain/awm027. DOI:   Google Scholar

Traugott U, Reinherz EL, Raine CS. Multiple sclerosis: Distribution of T cell subsets within active chronic lesions. Science. 1983;219(4582):308-310. doi: 10.1126/science.6217550. DOI:   Google Scholar

Lucchinetti C, Brück W, Parisi J, Scheithauer B, Rodriguez M, Lassmann H. Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination. Ann Neurol. 2000;47(6):707-717. doi: 10.1002/1531-8249(200006)47:6<707::aid-ana3>;2-q. DOI:<707::AID-ANA3>3.0.CO;2-Q   Google Scholar

Matsui M, Mori KJ, Saida T. Cellular immunoregulatory mechanisms in the central nervous system: Characterization of noninflammatory and inflammatory cerebrospinal fluid lymphocytes. Ann Neurol. 1990;27(6):647-651. doi: 10.1002/ana.410270611. DOI:   Google Scholar

Antel JP, Nicholas MK, Bania MB, Reder AT, Arnason BG, Joseph L. Comparison of T8+ cell-mediated suppressor and cytotoxic functions in multiple sclerosis. J Neuroimmunol. 1986;12(3):215-224. doi: 10.1016/s0165-5728(86)80005-4. DOI:   Google Scholar

Koch-Henriksen N. The Danish multiple sclerosis registry: A 50-year follow-up. Mult Scler. 1999;5(4):293-296. doi: 10.1177/135245859900500418. DOI:   Google Scholar




How to Cite

Arsovski, D. (2023). Assessment of sexual life and social life in people with multiple sclerosis. Health Promotion & Physical Activity, 21(4), 38–45.



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