Badanie wpływu promieniowania UV oraz temperatury na degradację preparatów farmaceutycznych zawierających aspirynę metodami spektroskopii FTIR i chemometrycznymi

Justyna Łoch; Anna Michońska; Rafał Kurczab

doi:10.5604/01.3001.0010.7709

Authors

Justyna Łoch State Higher Vocational School in Tarnow, Institute of Mathematical and Natural Science, Poland
Anna Michońska State Higher Vocational School in Tarnow, Institute of Mathematical and Natural Science, Poland
Rafał Kurczab State Higher Vocational School in Tarnow, Institute of Mathematical and Natural Science, Poland https://orcid.org/0000-0002-9555-3905

DOI:

https://doi.org/10.5604/01.3001.0010.7709

Keywords:

FTIR spectroscopy, chemometrics, principal component analysis, cluster analysis, aspirin, UV ageing

Abstract

The UV radiation and temperature are well-known external factors, which adversely affect the chemical stability of food, pharmaceuticals and various construction materials. In particular, the exposure to UV radiation may cause degradation of chemical substances and thus lead to reduced strength, the content of active substance or also to the formation of harmful substances for health. In the present study, the effect of exposure to UV radiation and increased temperature of six pharmaceutical products containing aspirin were investigated. To measure the changes occurring during exposure, the Fourier transform infrared spectroscopy (FTIR) combined with chemometrics methods, i.e. principal component analysis (PCA) and cluster analysis (CA) were used. An additional examined factor was the impact of tablet coating and exposure time on the degree of change in the chemical composition of the pharmaceutical products. The results showed that both the temperature and UV radiation influenced significantly the composition of pharmaceutical formulations, which vary considerably depending on the exposure time and the presence of covering layer of the drug. More substantial changes in the composition of the tablets were observed for longer exposure to the degrading factors and lack of covering. The methodology can be successfully used as a quick quality control of stored pharmaceutical products.

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